Research at the Department of Biological Chemistry integrates inorganic biochemistry, biophysics, and molecular biology. We focus on metal-dependent protein regulation, including structure, stability, and activity. Key questions include how metalloproteins acquire metal ions in cellular environments and how these ions modulate function.

Our work also involves developing molecular tools for regioselective, multifunctional protein labeling using chemical and enzymatic approaches. We design analytical methods to monitor intracellular metal ion dynamics and investigate metalloprotein stability and complex formation.

To address these challenges, we combine protein engineering, synthetic chemistry, structural mass spectrometry, biophysical techniques, molecular biology, and computational modeling.